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Inhibition of poly (ADP-ribose) polymerase-1 enhances doxorubicin activity against liver cancer cells

✍ Scribed by J.A. Muñoz-Gámez; R. Quiles-Pérez; A. Ruiz-Extremera; A.B. Martín-Álvarez; Laura Sanjuan-Nuñez; A. Carazo; Josefa León; F.J. Oliver; J. Salmerón

Book ID
116335559
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
921 KB
Volume
301
Category
Article
ISSN
0304-3835

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Effect of hyperthermia and doxorubicin o
Effect of hyperthermia and doxorubicin on nucleoid sedimentation and poly (ADP-ribose) Polymerase activity in L1210 cells
✍ J. Patrick Daugherty; Thomas A. Simpson; Dail W. Mullins 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 428 KB

We report on the individual and combined effects of doxorubicin (DOX) and hyperthermia (HYP) on nucleoid sedimentation and poly (ADP-ribose) polymerase (PARP) activity of L1210 cells. The effects of HYP and DOX on nucleoid sedimentation (increased sedimentation) were similar and correlated with cell