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Inhibition of platelet aggregation by L-arginine and polyamines in alloxan treated rats

✍ Scribed by J. D. Méndez; E. Zarzoza


Book ID
111742531
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
418 KB
Volume
43
Category
Article
ISSN
1521-6543

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The mycotoxin ochratoxin A (OA) consists of 5-chloro-3-methyl-3,4-dihydro-8-hydroxyisocoumarin moiety linked by an amide bond to p-Lphenylalanine. When added to washed rat platelets in vitro, OA caused a dose-dependent inhibition of aggregation induced by agonists such as adenosine diphosphate (ADP)