A new strategy for the synthesis of 4,6-
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Masatoshi Murakata; Masahiro Kimura
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Article
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2010
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Elsevier Science
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French
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An efficient alternative route to 4,6-di-tert-butyl-2,2-dipentyl-2,3-dihydro-5-benzofuranol (BO-653), a potent antiatherogenic antioxidant, has been developed by the application of the base-promoted dienone-phenol rearrangement reaction. A decisive effect of MgBr 2 in the reaction of Grignard reagen