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Inhibition of plasma lipid peroxidation by anti-atherogenic antioxidant BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran

โœ Scribed by Nanako Itoh; Yasukazu Yoshida; Mieko Hayakawa; Noriko Noguchi; Tatsuhiko Kodama; Osamu Cynshi; Etsuo Niki


Book ID
113487269
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
145 KB
Volume
68
Category
Article
ISSN
0006-2952

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An efficient alternative route to 4,6-di-tert-butyl-2,2-dipentyl-2,3-dihydro-5-benzofuranol (BO-653), a potent antiatherogenic antioxidant, has been developed by the application of the base-promoted dienone-phenol rearrangement reaction. A decisive effect of MgBr 2 in the reaction of Grignard reagen