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Inhibition of phospholipase C activity by auriculatin and 8-prenylluteone isolated from Erythrina senegalensis

✍ Scribed by Won Keun Oh; Hyun Sun Lee; Bo Yeon Kim; Hye Kyung Chang; Yong Hae Kim; Jean Wandji; J. Tanyl Mbafor; Z. Tanee Fomum; Jong Seog Ahn

Book ID: 101289361
Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 121 KB
Volume: 12
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(19980201)12:1<9::aid-ptr175>3.0.co;2-#

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✦ Synopsis

Auriculatin and 8-prenylluteone were isolated from Erythrina senegalensis (Leguminosae) as inhibitors of phospholipase C (PLC) and phosphoinositides (PI)-turnover in PLC-␥1 overexpressing NIH3T3 fibroblasts (NIH3T3␥1). Auriculatin (1) and 8-prenylluteone (2) showed inhibitory activity with an IC 50 value of 20 M on PLC in vitro as well as the formation of inositol phosphates in platelet-derived growth factor (PDGF)-stimulated NIH3T3␥1 cells. They also showed a moderate cytotoxicity against several human tumour cell lines with an IC 50 of 9.0-20 M, i.e. PC-3 (prostate), NCI-H226 (lung), CRL1579 (melanoma) in vitro.

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