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Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C

✍ Scribed by Shuhei Yamada; Kenji Hirota; Kazuhiro Chida; Toshio Kuroki

Book ID: 117057736
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 458 KB
Volume: 157
Category: Article
ISSN: 0006-291X
DOI: 10.1016/s0006-291x(88)80003-2

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## Abstract Ornithine decarboxylase (ODC) inductions by cholera toxin and by the phorbol ester tumor promoter, TPA, were compared in wild‐type Chinese hamster ovary (CHO) cells and in mutant cells having altered cyclic AMP‐dependent protein kinase activity. The aim of these studies was to determine