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Inhibition of Pgp activity and cell cycle-dependent chemosensitivity to doxorubicin in the multidrug-resistant LoVo human colon cancer cell line

✍ Scribed by G. Toffoli; G. Corona; M. Gigante; M. Boiocchi

Book ID
116167911
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
833 KB
Volume
32
Category
Article
ISSN
0959-8049

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## Abstract Multidrug resistant (MDR) tumor cells exhibit an altered pH gradient across different cell compartments, which favors a reduced intracellular accumulation of antineoplastic drugs and a decreased therapeutic effect. In our study, we have observed that the activity and expression of Na^+^