Inhibition of parathyroid hormone stimulated bone resorptionin vitroby the antibiotic mithramycin
โ Scribed by Cedric Minkin
- Publisher
- Springer
- Year
- 1973
- Tongue
- English
- Weight
- 1018 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1432-0827
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## Abstract Parathyroid hormone (PTH) stimulates bone formation in both animals and humans, and the expression of a number of genes has been implicated in the mediation of this effect. To discover new bone factors that initiate and support this phenomenon, we used differential display reverse trans
The cytokine interleukin-6 (IL-6) was produced by neonatal mouse parietal bones during a 6- or 48-hour culture period in response to prostaglandin E2 (PGE2) and bovine parathyroid hormone (PTH) 1-34 fragment but not 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. At the same time there was an increase in ta