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Inhibition of PAK-1 by Mesalazine Increases Cell Adhesion in Colorectal Cancer Cells

✍ Scribed by Khare, Vineeta ;Lyakhovich, Alex ;Lang, Michaela ;Tichy, Boris ;Pospisilova, Sarka ;Luciani-Torres, M Gloria ;Gasche, Christoph

Book ID: 122256932
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 83 KB
Volume: 140
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(11)61653-3

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## Abstract Vascular endothelial growth factor (VEGF) inhibitors, such as bevacizumab, have improved outcomes in metastatic colorectal cancer (CRC). Recent studies have suggested that VEGF can delay the onset of cellular senescence in human endothelial cells. As VEGF receptors are known to be upreg