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Inhibition of p75NTR in glia potentiates TrkA-mediated survival of injured retinal ganglion cells

✍ Scribed by Frédéric Lebrun-Julien; Barbara Morquette; Annie Douillette; H. Uri Saragovi; Adriana Di Polo

Book ID
116735579
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
878 KB
Volume
40
Category
Article
ISSN
1044-7431

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## Background: Neurotrophins mediate their effects by binding to members of the trk family of receptor tyrosine kinases and to the low-affinity nerve growth factor receptor p75. nerve growth factor (ngf) has been demonstrated to support survival and differentiation of neuroblastoma (nb) cells by ac