The erbB-2/neu oncogene is frequently over-expressed in many different tumors in humans, including those of breast and ovary. The oncogene encodes a receptor tyrosine kinase closely related to the epidermal-growth-factor receptor. We studied effects on differentiation and cell death of erbB-2/neu du
✦ LIBER ✦
Inhibition of ornithine decarboxylase by α-difluoromethylornithine induces apoptosis of HC11 mouse mammary epithelial cells
✍ Scribed by T. Płoszaj; T. Motyl; W. Zimowska; J. Skierski; L. Zwierzchowski
- Book ID
- 106222486
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 201 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0939-4451
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## Abstract MCF‐ 10A is a spontaneously immortalized, non‐transformed human mammary epithelial cell line. We have recently obtained MCF‐ 10A clones (MCF‐ 1OA HE cells) that are transformed following over‐expression of both a human point‐mutated c‐Ha‐__ras__ and the c‐__erb__B‐2 proto‐oncogenes. Two