Inhibition of nucleic acids synthesis inChlorellaby 2,4-dinitrophenol a unique concentration effect on DNA synthesis

✍ Scribed by Fricdrich Wanka; Pieter Thijssen

• Book ID: 104759194
• Publisher: Springer
• Year: 1980
• Tongue: English
• Weight: 576 KB
• Volume: 125
• Category: Article
• ISSN: 0302-8933
• DOI: 10.1007/bf00403201

✦ Synopsis

Nucleic acids and protein synthesis in synchronously growing Chlorelta cells were inhibited by 2,4-dinitrophenol. RNA andprotein synthesis decreased gradually from about 100 % at 0.1 mM to almost 0 To at 10 mM dinitrophenol. DNA synthesis was strongly inhibited at 0.5 mM but less at 1 mM concentration of the inhibitor. Beyond 1 mM the inhibitory effect increased again. A transient exposure to 0.5 and 10 mM dinitrophenol was fully reversible and cell division after the inhibition proceeded normally except for a slight delay'.