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Inhibition of nuclear factor-kappa B induces inflammatory cell migration and exacerbates severe liver injury in hepatitis B virus transgenic mice

✍ Scribed by Shinichi Satake; Masahito Nagaki; Kiminori Kimura; Hisataka Moriwaki


Book ID
118087784
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
366 KB
Volume
37
Category
Article
ISSN
1386-6346

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Oxidative stress, with reactive oxygen intermediate formation, may represent a common mechanism by which liver injury is induced by diverse etiologies. Oxidative stress enhances nuclear factor kappa B (NF-KB) activity, and NF-KB activity has been shown to enhance the expression of cytotoxic cytokine