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Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats

✍ Scribed by Roberto Maggio; Fabio Fumagalli; Eugenio Donati; Pascaline Barbier; Giorgio Racagni; Giovanni U. Corsini; Marco Riva


Book ID
113127410
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
320 KB
Volume
679
Category
Article
ISSN
0006-8993

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πŸ“œ SIMILAR VOLUMES


Modification of kainate-induced behavior
✍ R.Duncan Kirkby; Robert A. Forbes; Swaminathan Subramaniam πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 848 KB

We assessed the effects of N(omega)-nitro-L-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), on behavioral and electrographic seizures elicited in mice by convulsant doses of kainate. In Expt. 1, L-NAME dose-dependently potentiated the convulsant effects of kainate (44 mg