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Inhibition of nitric oxide synthase accentuates endotoxin-induced sickness behavior in mice

✍ Scribed by Ribeiro, Deidiane E.; Maiolini, Viviane M.; Soncini, Roseli; Antunes-Rodrigues, José; Elias, Lucila L.K.; Vilela, Fabiana C.; Giusti-Paiva, Alexandre

Book ID
121302806
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
306 KB
Volume
103
Category
Article
ISSN
0091-3057

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We assessed the effects of N(omega)-nitro-L-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), on behavioral and electrographic seizures elicited in mice by convulsant doses of kainate. In Expt. 1, L-NAME dose-dependently potentiated the convulsant effects of kainate (44 mg