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Inhibition of nicotinic receptor-mediated catecholamine secretion by dryobalanops aromatica in bovine adrenal chromaffin cells

✍ Scribed by Kyu-Suk Oh; Tae-Ju Park; Bo-Hwa Choi; Dong-Kyu Lee; Tae-Kyun Lee; Kyong-Tai Kim

Book ID
118770897
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
167 KB
Volume
42
Category
Article
ISSN
1043-6618

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We investigated the effects of amitriptyline, a tricyclic antidepressant, on [3H]norepinephrine ([3H]NE) secretion and ion flux in bovine adrenal chromaffin cells. Amitriptyline inhibited [3H]NE secretion induced by 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) and 70 mM K+. The half maximal inhib