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Inhibition of nicotinic acetylcholine receptors and calcium channels by clozapine in bovine adrenal chromaffin cells

✍ Scribed by Tae-Ju Park; Seong-Il Bae; Se-Young Choi; Byung-Jo Kang; Kyong-Tai Kim


Book ID
113992615
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
299 KB
Volume
61
Category
Article
ISSN
0006-2952

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We investigated the effects of amitriptyline, a tricyclic antidepressant, on [3H]norepinephrine ([3H]NE) secretion and ion flux in bovine adrenal chromaffin cells. Amitriptyline inhibited [3H]NE secretion induced by 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) and 70 mM K+. The half maximal inhib