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Inhibition of NF-κB in T cells blocks lymphoproliferation and partially rescues autoimmune disease in gld/gld mice

✍ Scribed by Sivakumar Vallabhapurapu; Rolf-Peter Ryseck; Michal Malewicz; Debra S. Weih; Falk Weih


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
395 KB
Volume
31
Category
Article
ISSN
0014-2980

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## Inhibition of abnormal T cell development and autoimmunity in gld mice by transgenic T cell receptor p chain* Mice homozygous for the gld (generalized lymphoproliferative disease) mutation develop systemic autoimmune disease and severe lymphadenopathy due to an age-related accumulation in the p