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Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

✍ Scribed by Jun-Li Luo; Shin Maeda; Li-Chung Hsu; Hideo Yagita; Michael Karin


Book ID
113523465
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
574 KB
Volume
6
Category
Article
ISSN
1535-6108

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## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl