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Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP)

✍ Scribed by C. Klessen

Book ID: 104786620
Publisher: Springer
Year: 1980
Tongue: English
Weight: 714 KB
Volume: 66
Category: Article
ISSN: 1432-119X
DOI: 10.1007/bf00493244

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✦ Synopsis

Cytochemical methods were used to demonstrate the inhibitory effect of salicylazosulfapyridine (SASP) on the activity of neutral proteases produced by neutrophilic granulocytes (PMN proteases). The SASP metabolites (5-aminosalicylic acid and sulfapyridine), produced by splitting of SASP by bacteria in the colon, did not inhibit the activity of PMN proteases. Paradoxically, sulfapyridine intensified PMN protease activity. A similar effect however could not be demonstrated for 5-aminosalicylic acid.

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