Inhibition of nebulin and connectin (titin) for assembly of actin filaments during myofibrillogenesis
โ Scribed by T.M. Nwe; Y. Shimada
- Book ID
- 117841540
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 381 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-8166
No coin nor oath required. For personal study only.
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A rat polyclonal anti-M-line protein antiserum and three mouse monoclonal anti-titin antibodies (E2, F3, and A12) were used to study the spatiotemporal relationship between M-line proteins and titin during myofibril assembly in cultured chicken cardiomyocytes by immunofluorescence microscopy. In day
Titin is a giant molecule that spans half a sarcomere, establishing several specific bindings with both structural and contractile myofibrillar elements. It has been demonstrated that this giant protein plays a major role in striated muscle cell passive tension and contractile filament alignment. Th