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Inhibition of murine RNA tumor virus replication and oncogenesis by chloroquine

✍ Scribed by Nelson H. Pazmiño; John M. Yuhas; Raymond W. Tennant

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
450 KB
Volume
14
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The effects of 7‐chloro‐4‐(4‐diethylamino‐l‐methylbutylamino) quinoline diphos‐phate (chloroquine) on marine RNA oncogenic virus infection and replication were studied in cell culture and in vivo. Replication ofMoloney leukemia virus in cell culture was inhibited by approximately 75% at a drug concentration of 1 s̈/ml. This concentration had no effect on cellular DNA or RNA synthesis or on cell division. Chloroquine at a dose of 50 mg/kg body weight given 15 min after injection of Moloney murine sarcoma virus prevented tumor development in newborn mice; similar treatment inhibited the induction of splenomegaly by Rauscher leukemia virus in adult mice. The effect of the drug is not exerted on the virus particle itself, since incubation of the virus with chloroquine for 30 min prior to infection did not decrease its oncogenicity. Presumably, the drug affects one or more events in virus replication.

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