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Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by Nucleoside, Nucleotide, and Non-Nucleoside Reverse Transcriptase Inhibitors

โœ Scribed by Weiss, J.; Theile, D.; Ketabi-Kiyanvash, N.; Lindenmaier, H.; Haefeli, W. E.


Book ID
126746007
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2006
Tongue
English
Weight
368 KB
Volume
35
Category
Article
ISSN
0090-9556

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## Abstract Docetaxel is one of the most widely used anticancer drugs. A major problem with docetaxel treatment, however, is the considerable interpatient variability in docetaxel exposure. Another disadvantage of the drug is that it has a very low oral bioavailability and can, therefore, only be a