Inhibition of monoamine oxidase by the R and S enantiomers of N[3-(2,4-dichlorophenoxy)propyl]-N-methyl-3-butyn-2-amine
β Scribed by P Dostert; EM O'Brien; KF Tipton; M Meroni; P Melloni; M Strolin Benedetti
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 780 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0223-5234
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The synthesis of the title compounds was accomplished in four steps. The synthetic route involves the preparation of Schiff's base by reacting salicylaldehyde with __m__βchloroaniline in EtOH. The Schiff's base was then reduced with NaBH~4~/MeOH. In the second step, PCl~3~ was reacted w
The partial ergoline LY228729 (1) which was a potent 5HT 1A agonist has been studied clinically. Somewhat later, a related analog, (S)-di-n-propyl-(8-isoxazol-5-yl-1,2,3,4-tetrahydronaphthalen-2-yl)amine (2a) which in addition to potent 5HT 1A agonist activity was a muscarinic antagonist, was chosen