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Inhibition of Monoamine Oxidase A by β-Carboline Derivatives

✍ Scribed by Hoon Kim; Sergey O. Sablin; Rona R. Ramsay


Book ID
115566410
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
143 KB
Volume
337
Category
Article
ISSN
0003-9861

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Inhibitors of monoamine oxidase III: 9-s
✍ Beng T. Ho; William M. McIsaac; L. Wayne Tansey; K. E. Walker 📂 Article 📅 1969 🏛 John Wiley and Sons 🌐 English ⚖ 337 KB

A series of 9-alkyl aromatic 8-carbolines was synthesized and evaluated as inhibitors of mitrochondrial monoamine oxidase. The possible existence of a hydrophobic or hydrophilic region on the enzyme was explored. Substitution of an electron-withdrawing group such as acetyl on N-9 position reduced t