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Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol

✍ Scribed by Thilo Hagen; Gabriela D’Amico; Marisol Quintero; Miriam Palacios-Callender; Veronica Hollis; Francis Lam; Salvador Moncada

Book ID
116289050
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
963 KB
Volume
322
Category
Article
ISSN
0006-291X

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Characterization of in vitro and in vivo
Characterization of in vitro and in vivo metabolic pathways of the investigational anticancer agent, 2-methoxyestradiol
✍ Nehal J. Lakhani; Alex Sparreboom; Xia Xu; Timothy D. Veenstra; Jürgen Venitz; W 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB

The aim of this study was to characterize the metabolic pathways of 2methoxyestradiol (2ME2), an investigational anticancer drug. In vitro metabolism studies were performed by incubation of 2ME2 with human liver microsomes under various conditions and metabolite identification was performed using li