To identify a role for amino acids in cholestasis associated with total parenteral nutrition, we measured bile formation by the isolated perfused rat liver in the presence and absence of added amino acids. All livers were infused constantly with sodium [14C]taurocholate (0.28 mumoles per min) for 90
โฆ LIBER โฆ
Inhibition of mitochondrial function in isolated rat liver mitochondria by azole antifungals
โ Scribed by Rodriguez, Rosita J. ;Acosta, Daniel
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 107 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0887-2082
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Methotrexate (MTX) and cyclosporine (CyA) are coadministered in a number of diseases. In this study, the effects of CyA on the hepatobiliary disposition of MTX were investigated in an isolated perfused rat liver model. A bolus 5-mg dose of MTX was added to a recirculating perfusate in the absence or