Inhibition of mitochondrial calcium uptake rather than efflux impedes calcium release by inositol-1,4,5-trisphosphate-sensitive receptors
โ Scribed by Susan Chalmers; John G. McCarron
- Book ID
- 113525815
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 763 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0143-4160
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The binding of many ligands to cellular receptors induces a signaling cascade which generates inositol 1,4,5-trisphosphate (IP 3 ). IP 3 binding to its receptors in various internal compartments causes a rapid Ca 21 efflux into the cytosol. We now demonstrate that chloroquine blocks ligand-induced C
## Abstract Recently, ATP has gained much interest as an extracellular messenger involved in the communication of calcium signals between cells. The mechanism of ATP release is, however, still a matter of debate. In the present study we investigated the possible contribution of connexin hemichannel