In order to investigate the interaction between the nervous and immune systems, we have analyzed the effect of one of the neuropeptides, pituitary adenylate cyclase activating polypeptide (PACAP), on microglia cells by the patch-clamp method. Puff application of PACAP38 onto mouse microglial cells i
β¦ LIBER β¦
Inhibition of microglial CD40 expression by pituitary adenylate cyclase-activating polypeptide is mediated by interleukin-10
β Scribed by Woong-Ki Kim; Doina Ganea; G.Miller Jonakait
- Book ID
- 114137613
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 357 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0165-5728
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## Abstract Pituitary adenylate cyclaseβactivating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptorβmediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374β11384). To check if PACAP might also modulate AMPA recept