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Inhibition of micro-RNA-induced RNA silencing by 2′-O-methyl oligonucleotides inDrosophilaS2 cells

✍ Scribed by Edward M. Berger; Edward B. Dubrovsky; Lara Appleby; Veronica Dubrovskaya

Book ID
119987319
Publisher
Society for In Vitro Biology
Year
2005
Tongue
English
Weight
952 KB
Volume
41
Category
Article
ISSN
1475-2689

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The antisense oligonucleotide 2'-O-methyl-RNA is a selective telomerase inhibitor targeting the telomerase RNA component and represents a potential candidate for anticancer therapy. The poor cellular uptake of 2'-O-methyl-RNA is a limiting factor that may contribute to the lack of functional efficac