Methotrexate (MTX), a chemotherapeutic agent used to treat cancer, produces cytogenetic damage and has a cytostatic effect in a variety of test systems. Several antigenotoxic agents have been studied in various in vitro and in vivo systems. However, data are limited regarding their ability to modula
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Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells
โ Scribed by Channa Keshava; Nagalakshmi Keshava; Wen-Zong Whong; Joginder Nath; Tong-man Ong
- Book ID
- 114071411
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 221 KB
- Volume
- 397
- Category
- Article
- ISSN
- 0027-5107
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## Abstract Chemotherapy often induces bone growth defects in pediatric cancer patients; yet the underlying cellular mechanisms remain unclear and currently no preventative treatments are available. Using an acute chemotherapy model in young rats with the commonly used antimetabolite methotrexate (