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Inhibition of Methionine Adenosyltransferase by the Polyamines

โœ Scribed by Arthur M. Geller; H.Leighton Legros Jr.; Karl Wherry; Malak Y. Kotb

Book ID
115566617
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
105 KB
Volume
345
Category
Article
ISSN
0003-9861

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## Abstract Two genes (__MAT1A__ and __MAT2A__) encode for the essential enzyme methionine adenosyltransferase (MAT). __MAT1A__ is silenced in hepatocellular carcinoma (HCC), and absence of __MAT1A__ leads to spontaneous development of HCC in mice. Previous report correlated promoter methylation to