We have analyzed the ability of a recombinant replication-defective adenovirus to transfer the thymidine kinase gene of herpes simplex virus (HSV-tk) into hepatocellular carcinoma (HCC) cells to confer sensitivity to ganciclovir. Three HCC cell lines (Hep3B, PLC/PRF/5, and HepG2) were efficiently in
Inhibition of metastatic progression of SSTR2 gene transfection mediated by adenovirus in human pancreatic carcinoma cells
β Scribed by Feng Yanping; Huang Tao; Gao Jun; Chang Qing; Qin Renyi
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- Chinese
- Weight
- 630 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0510-9752
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## BACKGROUND Previous reports indicate that Genistein, a naturally occurring isoflavonoid, exhibits strong antiangiogenic activity. The underlying mechanism of inhibition, however, remains unclear. Among the biologic effects of Genistein are the inhibition of tyrosine kinases and the
We have examined the anti-tumor effect in nude mice caused by human pancreatic cancer cells (AsPC-1) modified to secrete IL-2 or IL-4. Loss of tumorigenicity of cytokineproducing, but not wild-type, cells was observed despite their unaltered in vitro proliferation rates; and these anti-tumor effects
HCC patients are generally resistant to chemotherapy, Selective expression of cytotoxic gene products in tuwhich, in some cases, may be the result of a loss of function mor cells is one of the goals of gene therapy for treating mutation in the p53 gene. cancer. We are developing such a strategy for
## Abstract In our study, we examined whether human hepatocellular carcinoma (HCC) expresses peroxisome proliferatorβactivated receptor Ξ³ (PPARΞ³) and the effects of PPAR Ξ³ activation by its selective ligands on cell growth and cell invasion in HCC cells. RTβPCR and Western blot analysis revealed th