Inhibition of metalloproteinase by futoenone derivatives

✍ Scribed by Li-An Yeh; James Chen; Frans Baculi; Diane E. Gingrich; T.Y. Shen

• Book ID: 103983013
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 234 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(95)00282-x

✦ Synopsis

Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases. The molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes.