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Inhibition of MAP Kinase Kinase Causes Morphological Reversion and Dissociation between Soft Agar Growth and in Vivo Tumorigenesis in Angiosarcoma Cells

โœ Scribed by Kenneth R. LaMontagne Jr.; Marsha A. Moses; Dmitri Wiederschain; Sudipta Mahajan; Jeannine Holden; Hamid Ghazizadeh; David A. Frank; Jack L. Arbiser


Book ID
117022398
Publisher
American Society for Investigative Pathology
Year
2000
Tongue
English
Weight
761 KB
Volume
157
Category
Article
ISSN
0002-9440

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Basic fibroblast growth factor (bFGF, FGF-2) is progressively lost from mammary epithelial cells as they become malignant. To investigate the effects of restoring the expression of bFGF in breast cancer cells, we constructed MCF-7 cells that permanently overexpress 18-kD cytoplasm-localizing bFGF (M