Inhibition of male corpora allata activity and sexual pheromone responsiveness in the black cutworm, Agrotis ipsilon, by the hypocholesterolemic agent, fluvastatin
✍ Scribed by Line Duportets; Marie-Cécile Dufour; Jean-Marc Bécard; Christophe Gadenne; Franck Couillaud
- Book ID
- 102661524
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 585 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0739-4462
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✦ Synopsis
Male sexual behavior of the black cutworm Agrotis ipsilon is controlled by corpora allata. Allatectomies performed on day-1 and day-3 males inhibited the typical sexual behavior in day-4 males when exposed to female pheromone in a wind tunnel. Both JH-Ill and jH-Ill acid were able to restore male sexual behavior, suggesting that corpora allata act through their endocrine ac- tivity. We demonstrated that corpora allata incubated in vitro produced only the acid form of JH-Ill and JH-11. Fluvastatin, an HMG-CoA reductase inhibitor, inhibited j t i acid biosynthesis by the corpora allata when fluvastatin was added to incubation medium or injected in males 4 h before the bioassay. However, endocrine activity of CA resumed 5-6 h after injection, indicating that the effect of fluvastatin was temporary. Fluvastatin injection also induced temporary inhibition of male responsiveness. o