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Inhibition of LPS-induced iNOS and NO synthesis in primary rat microglial cells

✍ Scribed by Klaus Lieb; Stefanie Engels; Bernd L Fiebich


Book ID
117409831
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
194 KB
Volume
42
Category
Article
ISSN
0197-0186

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The effect of cannabinoids on the induction of cytokine mRNA by rat microglial cells was examined. Exposure of neonatal rat cortical microglial cells to the exogenous cannabinoid ␦ 9 -tetrahydrocannabinol (THC) resulted in reduced amounts of lipopolysaccharide (LPS)-induced mRNAs for IL-1␣, IL-1␀, I