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Inhibition of leukocyte adhesion: an alternative mechanism of action for anti-inflammatory drugs

✍ Scribed by Federico Dı́az-González; Francisco Sánchez-Madrid

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
166 KB
Volume
19
Category
Article
ISSN
0167-5699

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✦ Synopsis

It has been widely accepted that the mechanism of action of nonsteroidal anti-inflammatory drugs (NSAIDs) is the inhibition of prostaglandin synthesis. However, a significant body of evidence suggests that NSAIDs have additional anti-inflammatory mechanisms of action. Here, Federico Díaz-González and Francisco Sánchez-Madrid discuss novel effects of NSAIDs on leukocyte adhesion pathways that may help in the development of new anti-inflammatory agents that selectively block cell adhesion molecules.

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