## Abstract Larvae of __Xenopus laevis__ at stages 50β53 were lentectomized and then injected with tritiated thymidine at various times after lentectomy. In Series I, the animals were injected 1, 2, 3, 4, 6, 8, 10, 12, 15, or 17 days after lens removal and fixed three hours after injection. Autorad
Inhibition of lens regeneration in larvalXenopus laevis
β Scribed by Cioni, Carla ;Filoni, Sergio ;Bosco, Luigi
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 900 KB
- Volume
- 220
- Category
- Article
- ISSN
- 0022-104X
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β¦ Synopsis
Abstract
The present research aims at showing the role played by the lens in inhibiting lensβforming transformations of the outer cornea of Xenopus laevis tadpoles. Two types of experiment were carried out: 1) lentectomy and insertion of a Millipore filter disk at the side of the lens, and 2) lentectomy and insertion of a Millipore disk with a central hole. Results indicate that when the lens is replaced by a mechanical obstacle capable of preventing direct communication between vitreous and anterior chambers, definite inhibition of the lensβforming transformations of the outer cornea occurs. These data strongly suggest that the inhibition exerted by the lens on lensβforming transformations of the outer cornea in Xenopus laevis eyes is mechanical rather than chemical in nature.
π SIMILAR VOLUMES
## Abstract Three different types of experiments were carried out to investigate the role of the lens in lensβforming transformations of the outer cornea of __Xenopus laevis__ tadpoles (at stage 51, as defined by Nieuwkoop and Faber, '56): 1) simple lentectomy; 2) incision of outer and inner cornea
## Abstract The lensβforming capacity of the pericorneal epidermis of __Xenopus laevis__ larvae at stage 51 has been investigated. The results obtained show that, whether or not the lens is present, the pericorneal epidermis can form a lens when it is in direct contact with the vitreous chamber of
## Abstract After lentectomy through the pupillary hole, the outer cornea of larval __Xenopus laevis__ can undergo transdifferentiation to regenerate a new lens. This process is elicited by inductive factor(s) produced by the neural retina and accumulated into the vitreous chamber. During embryogen
Lumbar ganglia innervating regenerating and normal hindlimbs were removed from larval Xenopus laevis at stage 56-57 (according to Nieuwkoop and Faber, '56) and implanted between the outer and inner corneas of larvae of the same species at stage 50. The control experiments consisted of implanting fra
Early limbs of larval Xenopus laevis can form a regeneration blastema in the absence of nerves. The nerve-independence could be due to the synthesis of neurotrophic-like factors by the limb bud cells. To test this hypothesis, two series of experiments were performed. Series A: the right hindlimbs of