Inhibition of Large-Conductance Calcium-Activated Potassium Channel by 2-Methoxyestradiol in Cultured Vascular Endothelial (HUV-EC-C) Cells

Activation of large-conductance Ca2+-act

Activation of large-conductance Ca2+-activated K+ channels by pinacidil in human umbilical vascular endothelial cells

✍ Sheng-Nan Wu; Hui-Fang Li; Ai-Yu Shen 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 329 KB 👁 2 views

The effect of pinacidil, an opener of ATP-sensitive K + (K ATP ) channels, on large-conductance Ca 2+ -activated K+ (BK Ca ) channels was investigated in cultured endothelial cells of human umbilical veins. In whole cell configuration, pinacidil (30 µM) increased the amplitude of K + outward current