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Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells

✍ Scribed by Carter, B Z; Mak, D H; Woessner, R; Gross, S; Schober, W D; Estrov, Z; Kantarjian, H; Andreeff, M

Book ID: 109886847
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 448 KB
Volume: 23
Category: Article
ISSN: 0887-6924
DOI: 10.1038/leu.2009.101

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re