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Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells

✍ Scribed by Mingo-Sion, Amy M; Marietta, Peter M; Koller, Erich; Wolf, Douglas M; Van Den Berg, Carla L

Book ID: 110068228
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 327 KB
Volume: 23
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1207147

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## Abstract Recent studies have shown that MEK/ERK‐mediated signals play a major role in regulation of activity of p53 tumor suppressor protein. In this study, we investigated whether or not there is functional interaction between p53 and MEK/ERK pathways in epithelial breast cancer cells exposed t