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Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes

✍ Scribed by Luke H Chamberlain

Book ID
118519335
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
373 KB
Volume
507
Category
Article
ISSN
0014-5793

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πŸ“œ SIMILAR VOLUMES

Nigericin inhibits insulin-stimulated gl
Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes
✍ Chih-Ying Chu; Ying-Shun Kao; Jim C. Fong πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 187 KB

## Abstract We used nigericin, a K^+^/H^+^ exchanger, to test whether glucose transport in 3T3‐L1 adipocytes was modulated by changes in intracellular pH. Our results showed that nigericin increased basal but decreased insulin‐stimulated glucose uptake in a time‐ and dose‐dependent manner. Whereas