Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs
โ Scribed by Yokota, Takanori; Sakamoto, Naoya; Enomoto, Nobuyuki; Tanabe, Yoko; Miyagishi, Makoto; Maekawa, Shinya; Yi, Li; Kurosaki, Masayuki; Taira, Kazunari; Watanabe, Mamoru
- Book ID
- 110033619
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 110 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1469-221X
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## Abstract ## Background There has been much research into the use of RNA interference (RNAi) for the treatment of human diseases. Many viruses, including hepatitis B virus (HBV), are susceptible to inhibition by this mechanism. However, for RNAi to be effective therapeutically, a suitable delive
Hepatitis C virus (HCV) replication is highly dependent on host cell factors. Identification of these host factors not only facilitates understanding of the biology of HCV infection but also enables the discovery of novel targets for anti-HCV therapy. To identify host genes important for HCV RNA rep