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Inhibition of Intestinal Pyrimidine Nucleoside Phosphorylases

✍ Scribed by M. Guill Wientjes; J. Lai-Sim Au

Book ID
114421411
Publisher
Springer US
Year
1987
Tongue
English
Weight
724 KB
Volume
04
Category
Article
ISSN
0724-8741

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To compare the activity of pyrimidine nucleoside phosphorylase (PNP), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), we used uridine (Urd), deoxyuridine (dUrd), and thymidine (dThd) as substrates and human, rat, and mouse neoplastic and normal tissues. As PNP activity was higher in t