Recombinant human interleukin-1 beta, a mediator of osteoblastic cell function, was found to regulate the expression of the cell adhesion receptors, integrins, on human osteosarcoma cells. Interleukin-1 beta (IL-1 beta) at picomolar concentrations, specifically elevated approximately six- to tenfold
โฆ LIBER โฆ
Inhibition of interleukin-1 type I receptor expression in human cell-lines by an antisense phosphorothioate oligodeoxynucleotide
โ Scribed by Loren Miraglia; Thomas Geiger; C.Frank Bennett; Nicholas M. Dean
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 839 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0192-0561
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## ) is a potent cytokine that stimulates interstitial collagenase-1 (matrix metalloproteinase-1; MMP-1). In this study, we compared the mechanism(s) by which IL-1b induces collagenase gene expression in two very different cells, normal human foreskin fibroblasts (HFFs) and an aggressive breast ca