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Inhibition of integrin-mediated adhesion and signaling disrupts retinal development

✍ Scribed by Ming Li; Donald S. Sakaguchi

Book ID
116975000
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
771 KB
Volume
275
Category
Article
ISSN
0012-1606

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## Abstract In metastatic cancer, high expression levels of vitronectin (VN) receptors (integrins), FAK, and ERK5 are reported. We hypothesized that integrin‐mediated ERK5 activation via FAK may play a pivotal role in cell adhesion, motility, and metastasis. ERK5 and FAK phosphorylation when metast