Inhibition of human serine proteases by SPAAT, the C-terminal 44-residue peptide from α1-antitrypsin

Binding of SPAAT, the 44-residue C-termi

Binding of SPAAT, the 44-residue C-terminal peptide of α1-antitrypsin, to proteins of the extracellular matrix

✍ Marilyn A. Niemann; Joseph E. Baggott; Edward J. Miller 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB 👁 1 views

SPAAT (short piece of a 1 -antitrypsin [AAT]), the 44-residue C-terminal peptide of AAT, was originally isolated from human placenta [Niemann et al. (1992): Matrix 12:233-241]. It was shown to be a competitive inhibitor of serine proteases [Niemann et al. (in press): Biochem Biophys Acta]. The bindi