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Inhibition of human renal epithelial Na+/Pi cotransport by phosphonoformic acid

✍ Scribed by Ahad N.K. Yusufi; Miroslawa Szczepanska-Konkel; Stephen A. Kempson; James A. McAteer; Thomas P. Dousa


Book ID
117056874
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
368 KB
Volume
139
Category
Article
ISSN
0006-291X

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Inhibition of renal Na+-Pi cotransporter
✍ Dr. Mahmoud Loghman-Adham πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 791 KB

## Abstract We studied the role of sulfhydryl groups in Na^+^‐Pi contransport across the renal brush border membrane (BBM), using HgCl~2~, an agent which penetrates membranes freely. HgCl~2~ inhibited the initial Na^+^‐dependent ^32^Pi transport in a dose‐dependent manner (IC~50~ = 54 ΞΌM). Na^+^‐in