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Inhibition of Human Leukocyte Elastase by Brunsvicamides A–C: Cyanobacterial Cyclic Peptides

✍ Scribed by Mihiret T. Sisay; Stephanie Hautmann; Christian Mehner; Gabriele M. König; Jürgen Bajorath; Michael Gütschow


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
341 KB
Volume
4
Category
Article
ISSN
1860-7179

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3R)-and (3S)-N-(2-chloromethylphenyl)-3-bromo-3-fluoroazetidin-2-ones 2 were synthesized via the separation of diastereoisomeric phenylglycinol derivatives of the starting 2,3-dibromo-2-fluoropropanoic acid. Acidic hydrolysis of the hydroxyamides led to the chiral trihalogenopropanoic acids. Then, a