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Inhibition of human fibroblasts sphingomyelinase by cholesterol and 7-dehydrocholesterol

โœ Scribed by J.C. Maziere; C. Wolf; C. Maziere; L. Mora; G. Bereziat; J. Polonovski


Book ID
118316098
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
289 KB
Volume
100
Category
Article
ISSN
0006-291X

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Calmodulin antagonists chlorpromazine an
โœ M. Masson; B. Spezzatti; J. Chapman; C. Battisti; N. Baumann ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 461 KB

In this report we showed that calmodulin antagonists chlorpromazine (CPZ) and W-7 (N-[6-aminohexyl]-5-chloro-l-naphtalenesulfonamide), when added to fibroblast cell cultures, gave rise to a time-and dosedependent decrease of sphingomyelinase activity. CPZ and W-7 also significantly inhibited LDL-and